·v at the beginning of the book
In publishing the translation ·vii

01 You must know the difference between health and disease to create medicine.
1.
The difference between health and disease, and their treatment
2.
The Insulin Story
3.
Medicines that we didn't know were effective
4.
Two groundbreaking new drugs strategically developed in Japan
5.
I recommend pharmacy for your future

02 Synthesize the drug
1.
The birth path of medicine
2.
A new trend in the creation of the New Testament
3.
Society's Call for Pharmaceutical Synthesis
4.
The need for the development of groundbreaking synthetic techniques

03 Unraveling the structure of the protein that serves as the drug's target
1.
View the three-dimensional structure of proteins
2.
Molecular structure of proteins
3.
The function of a protein is determined by its three-dimensional structure.
4.
X-ray crystal structure analysis is similar to microscopy.
5.
Making decisions is more difficult than interpreting them.
6.
Expectations for the large-scale synchrotron radiation station SPring-8
7.
As the resolution improves, hydrogen atoms can be seen.
8.
Capturing the Moment with Time-Division X-Ray Crystal Analysis
9.
The three-dimensional structure analysis of membrane proteins is a cutting-edge field of research.

04 Designing medicine
1.
What is drug design?
2.
Key and lock hole
3.
Drug design
4.
Finding compounds that become the seeds of medicine
5.
Designing medicine requires flexible thinking and passion.

05 Investigating why medicine works
1.
Find the point of action of the drug
2.
Pharmacological techniques as seen in the case of morphine research
3.
Discovery of the opioid receptor
4.
Using drugs and genes as tools to elucidate the mechanisms of life and disease.
5.
Ion channel genome discovery
6.
The Future of Ion Channel Drugs

06 Developing an antiviral drug
1.
Aren't infections scary anymore?
2.
Are viruses germs?
3.
Virus life cycle
4.
How do viruses reproduce?
5.
Let's eradicate viruses by uncovering the functions of viral proteins.
6.
Antiviral drugs that target proteins of the virus (HIV-1)
7.
What can we learn from the experience of researching and developing anti-HIV-1 drugs?
8.
The key to antiviral drug development is the membrane fusion step.
9.
Targets the virus's enzymes (proteins)
10.
As we enter an era of frequent outbreaks of new and re-emerging infectious diseases,

07 The world is surprised by the development of a treatment for Alzheimer's disease.
1.
What is Alzheimer's disease?
2.
Colin hypothesis
3.
The discovery of seed compounds is the starting point of research.
4.
Give up the most powerful compound
5.
The discovery of donepezil
6.
Pharmacological action of donepezil
7.
Clinical trials of donepezil
8.
Approved Alzheimer's disease treatments
9.
PharmaDream (Dream of Drug Creation)

08 Creating Antibacterial Agents by Observing Biodefense Mechanisms
1.
Discovery of the antimicrobial peptide, magainin
2.
Antimicrobial peptides effective against a variety of microorganisms
3.
Identify bacteria with plus and minus
4.
Peptides that open holes in membranes
5.
The combination of two peptides produces dramatic effects.
6. Antimicrobial peptides that target DNA
7.
Tachypressin 1, a greedy antimicrobial peptide that targets both membranes and DNA
8.
Let's develop antimicrobial peptides as antibacterial agents.

09 Letting the drug move through my body as it pleases, DDS
1.
The difference between drugs and medicines
2.
Drug Movement in the Body and DDS
3.
Targeting - DDS that shoots at the target of the drug
4.
Biopharmaceuticals and DDS
5. DNA and DDS - Making Medicine with Genes

10 Genomes Will Transform Medicine and Drug Development
1.
Genomic drug discovery and personalized medicine or personalized pharmacology
2.
What happens when you decode the human genome?
3.
Personalized medicine using genomic information
4.
Genome development using genome information
5.
Specific examples of pharmacogenomics
6.
Specific examples of genome-based medicine
7.
Future outlook

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To the end of the translation
List of Authors ·310

“This is an introduction to pharmacy.
Presenting a vision for new drug development to future pharmacy students.
“An easy-to-understand explanation of the characteristics of pharmaceutical education.”

It will be of great help to those involved in the field, from students dreaming of entering pharmacy school to undergraduate and graduate students at pharmacy schools, and even those working in new drug development, in understanding the overall concept of new drug creation.
Yoon Yeo-pyo (Chairman of the Osong Advanced Medical Industry Promotion Foundation, former Commissioner of the Korea Food and Drug Administration, Doctor of Pharmacy)

In Japanese, a toothpick is called yōji (楊枝), which in Chinese characters means willow branch.
Isn't that funny? Later, I found out that willow branches actually contain aspirin.
… … The discovery that willow branches are effective for this pain may have been discovered by accident, but the fact that aspirin was born from this willow tree was not the result of repeated coincidences, but the result of persistent efforts by scientists.
(Reference text, pages 11-12)

Ten faculty members from Kyoto University's Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, focusing on their areas of expertise and sometimes drawing on their own experiences, explain "How to Create New Medicines."
Chapters 1 to 5 explain the history of medicine and the methodology of new drug development, while Chapters 6 to 8 are practical and explain the process of developing new drugs for specific diseases, such as developing treatments for infectious diseases.
Chapter 7 in particular is the story of Professor Sugimoto's development of the world's first treatment for Alzheimer's disease.
Chapters 9 and 10 describe drug delivery systems and genomic drug discovery, which are 21st-century drug discovery technologies.

There are many incurable diseases that are waiting for the development of groundbreaking cures, such as cancer, Alzheimer's disease, and AIDS.
Drug development requires comprehensive knowledge from many academic fields, including organic chemistry, physical chemistry, biochemistry, molecular biology, pharmacology, and pharmaceutical science.
The only place where these are systematically taught and researched is the College of Pharmacy.
As evidenced by the fact that the Nobel Prize has been awarded for the development of groundbreaking new drugs, pharmacy is a highly attractive academic field that allows for both academic contributions and social contributions in the form of disease treatment.
It goes without saying that the development of new drugs to “cure incurable diseases” is the most important field in pharmacy.
So, I planned this book with the hope of conveying the dream of pharmaceuticals that cures incurable diseases to as many people as possible.
I hope that more young people will read this book and decide to pursue a career in pharmacy.

This valuable book, which explains in an easy-to-understand manner the process from the creation (discovery and design) of new substances, the starting point of new drug development, to its development, is highly recommended reading for anyone considering new drug development.
Lee Jong-wook (President of Daewoong Pharmaceutical, Doctor of Pharmacy)

This book, "Medicine that Can Be Good or Bad for Our Body," was created to present the importance and vision of pharmacy education as the curriculum of our country's pharmacy schools changed from the previous 4-year system to a 6-year system (2+4 years).
The two goals of pharmacy education are that while conventional drug therapy has ignored the genetic characteristics of each patient according to their race or individual (genetic differences in absorption, distribution, metabolism, excretion, and drug responsiveness), the recently developed clinical pharmacy introduces optimal drug therapy according to the genetic characteristics of each patient.
Second, developing new drugs requires a huge amount of money and a long time, and therefore has a very high risk of failure.
The key to new drug development is to minimize the risk of failure and maximize the probability of success, and this explains the effort to cultivate experts with balanced knowledge of all aspects of new drug development.

Kyoto University's School of Pharmacy (Graduate School) has played a significant role in the development of new drugs in Japan, a country known for its strong development of new drugs. With the recent introduction of a six-year program, the school created this book to dispel the public's misconception that the six-year program is solely focused on clinical pharmacy.
Although the book mainly describes the case of Japan, it explains the entire process of new drug development in an easy-to-understand manner, so I think it will be of great help to people in Korea, especially students considering entering pharmacy school, current and graduate students in pharmacy schools, and even those working in the field of new drug development.