Chapter 1: Molecular-Biochemical Principles of Toxicology and the Central Dogma
1.
Molecular-Biochemical Principles of Toxicology and the Central Dogma
2.
Chemical bonds and chemical properties for toxicity expression
3.
Concept and Classification of Organic Chemicals and Toxic Substances
4.
The concept of biotransformation

Chapter 2 Phase I Reaction - Cytochrome P450-Dependent Biotransformation
1.
Discovery and classification of cytochrome P450
2.
Structure (topology) and substrate specificity of cytochrome P450
3.
Specificity of P450 in tissues, cells, and organelles
4.
Cytochrome P450 catalytic cycle
5.
Four major catalytic reactions by P450s
6.
P450 genes and induction mechanisms
7.
P450 activation inhibition mechanism
8.
Toxicants-drug metabolism enzyme families: CYP1, 2, 3
9.
P450 expression in extrahepatic tissues - CYP1, CYP2, and CYP3 families
10.
Induction and enzymatic degradation of P450

Chapter 3 Phase I Reaction - Biotransformation by Major Enzymes Other than Cytochrome P450
1.
Flavin mono-oxygenase
2.
Epoxide hydrolase
3.
Monoamine oxidase
4.
Ethanol-decomposing enzymes, including alcohol dehydrogenase and acetaldehyde dehydrogenase
5.
Quinone reductase
6.
Xanthine oxidoreductase

Chapter 4 Biotransformation by Phase II Reaction
1.
Glucuronic acid conjugation
2.
Sulfate conjugation
3.
Acetylation conjugation
4.
Methylation
5.
Amino acid conjugation
6. GSH conjugation reaction
7.
Gene-coordinate regulation of phase I and phase II responses

Chapter 5 Bioactivation - Reactive Intermediates
1.
Reactive intermediates－Electrophilic metabolites
2.
Carbon-centered radical and redox-active species

Chapter 6 Toxicodynamics - Reactive intermediates and their interactions with DNA, lipids, proteins, etc.
1.
DNA damage caused by active intermediate metabolites
2.
Protein and lipid damage caused by active intermediate metabolites

Chapter 7 Chemical Carcinogenesis
1.
multistage theory of carcinogenesis
2.
A Deeper Understanding of Carcinogenesis

References
index