1 Development and Structure of the Lymphatic System 1
2 Chemistry, Structure, and Function of Immunoglobulins 25
3 The Role of the Complement System in Cancer Causes and Management 57
4 The Science of Cancer and Innate Immunity 89
5 Cancer as a Tumor Antigen and Non-Self 131
6 Tumor Immunosurveillance 161
7 Essential Components of Adaptive Immunity and Their Relevance to Cancer Immunology 179
8. Evading Cancer-Immune Detection 217
9 Cancer Vaccines and Active Immunization 241
10 Key Clinical Components of Cancer Immunotherapy (Cell-Mediated Immune Regulatory Mechanisms) 265
11 Microbiome and Cancer Immunotherapy 303
12 Clinical Applications of Immunotherapeutics 323
13 The Impact of COVID-19 on Cancer Immunotherapy and Cancer Treatment 389

Glossary 418
Index 445

Clinical Immuno-Oncology provides focused, practical, up-to-date content on immunotherapies used to treat various cancer types, detailing the fundamental components of the human immune system that are involved in the efficacy of various immunotherapies and the latest research on how they work with the immune system to fight cancer.
Clinical Immuno-Oncology provides a detailed, accessible overview of the fundamental cell biology and molecular genetic mechanisms of the human immune system involved in the initiation and progression of cancer, with an emphasis on the development of tumor-specific antigens and the challenges associated with developing cancer immunotherapy.

This book explains the basics of cancer immunotherapy and discusses successful clinical cases in detail, and is recommended by experts with extensive experience in the field.
Lead author John E.
Niederhuber and co-authors have created this book to provide essential clinical information for implementing novel immunotherapies in clinical practice, making it an ideal resource for clinical oncologists, radiation oncologists, surgical oncologists, pathologists, and cancer nurses, as well as immunology researchers.

· Provides balanced, integrated content on the latest clinical science of immunotherapy, clinical and translational research, and evidence-based medicine.

· Clinical application of immunotherapies for frequently diagnosed cancer types, such as melanoma, lung cancer, breast cancer, pancreatic cancer, colon and rectal cancer, prostate cancer, leukemia, and other malignant blood tumors.

· Expert content from leading experts in the field of immunology detailing immune responses, innate immunity, active vaccines for cancer, and cell-based therapies.

· Topics that are becoming hot topics in clinical immuno-oncology, such as cancer immunotherapy, the latest immunotherapy, new scientific findings on the role of the microbiome in immunotherapy, recent advances in genetically engineered cell-based therapies, and active immune vaccines for cancer, when cancer patients are infected with COVID-19.

· The Korean version includes a glossary of terms related to immunology and immuno-oncology, as well as updated US FDA approvals for the latest cancer immunotherapies, including immuno-oncology agents, antibody-drug conjugates, and CAR-T cell therapies, as of September 2024.