Beyond the Limits of Modern Medicine
The AI-based hyper-personalized organ regeneration revolution has begun!

This book contains all the latest achievements of the next-generation medical innovations by startup Rocket Healthcare, combining cutting-edge technologies such as artificial intelligence, 3D bioprinting, and genome analysis.
This study sharply analyzes the problems of the existing medical system, such as the surge in medical expenses due to the aging population, the limitations of chronic diseases, and the inefficient structure of the pharmaceutical industry, and suggests the possibility of a hyper-personalized organ regeneration platform as an alternative.
Beyond simply explaining the technology, it proposes reasons why Korean society must transition to a hyper-personalized economy and strategies for implementing it.
It will provide valuable insights to medical and biotech industry professionals, policymakers, and general readers interested in the future of healthcare.

The author, Seok-Hwan Yoo, CEO of Rocket Healthcare, is a first mover who has developed long-term regenerative treatments for skin, cartilage, kidneys, and other organs for over 10 years since 2012, achieving clinical trials and global commercialization.
Using artificial intelligence bioprinting technology, we have successfully commercialized a treatment that regenerates diabetic feet, restores cartilage, and revives kidneys with a single procedure.
These treatments have fewer side effects, higher cure rates, and can dramatically reduce costs by up to 80% compared to existing treatments.

The golden rule for providing products cheaply and quickly in the global online platform market is hyper-personalization.
In reality, hyper-personalized services have already become a trend.
Amazon, Coupang, and American social media platforms are taking the lead in the market with predictive personalized marketing and services utilizing generative artificial intelligence and big data.
There are some concerns that come with it.
On an international level, issues such as monopoly, international taxation, and personal information leaks are becoming increasingly serious.


Hyper-personalization is also having a profound impact on legacy industries.
The semiconductor industry has also rapidly transformed from a mass production system to a customer-tailored semiconductor foundry, with Taiwan's TSMC leaping to the top of the world.
Korean semiconductor companies are struggling to reform their old paradigm of mass production, and this is cited as a cause of sluggish exports.
The electric vehicle revolution is also shifting from a hardware industry of secondary batteries and powertrains to personalized software mobility (SDV, Software Derived Vehicle).
Entertainment tailored to individual tastes and experiences, as well as convenient and useful apps, will shape the future of the mobility industry.
--- p.6

I define living systems as energy architectures that self-assemble, self-heal, self-regenerate, regenerate, and thrive.
In reality, our human body has the ultra-precision information processing ability to process 3 billion genetic information using the four basic bases A, T, C, and G with nano-level sophistication and quantum precision.
Additionally, they replicate and survive in the extracellular environment using various extracellular matrix (ECM) in the body.

Recently, epigenetic changes, which involve the acquisition of traits that regulate gene expression, have also been attracting attention. In addition to DNA and RNA mutations, these changes also involve local optimization, a process of collective intelligence among cells through neural tissue.
In summary, attempting to achieve perfect personalized organ regeneration with only two or three key substances or signals is bound to be fraught with difficulties and errors.
--- p.20

In 2012, I set out to create a new medical platform that would break away from the existing drug-centered treatment system.
For the past 10 years, we have been working to achieve a complete cure for complex chronic diseases by realizing the 'AI hyper-personalized organ regeneration revolution.'
As of 2024, the AI ​​organ regeneration platform has undergone clinical trials in over 10 countries and has received various medical device approvals from around 50 countries, including the European Food and Drug Administration, the U.S. Food and Drug Administration, and the Korea Food and Drug Administration, and is in the process of commercializing exports.


For example, diabetic foot (diabetic foot ulcer) is a complex chronic disease that affects approximately 150 million patients worldwide and approximately 500,000 patients in Korea.
Peripheral blood vessels and nerves are damaged, leading to internal tissue necrosis.
Tissues that have died due to diabetic foot disease are not easy to treat, so up to 40% of cases require amputation of the toes or ankles.
Moreover, once amputation is performed, the patient's five-year mortality rate soars to 50%.


Diabetic foot is one of the chronic, incurable diseases caused by complex circumstances.
Rocket Healthcare has developed a method to regenerate diabetic feet with just one treatment.
This method involves extracting the patient's extracellular matrix (ECM), inserting it into a 3D bioprinter, and then creating a regeneration niche patch to fill the affected area.
The treatment time does not exceed 30 minutes, and it has been confirmed through clinical trials in over 10 countries that the affected area is regenerated by more than 90% after 2 weeks at the earliest and 8 weeks at the latest.
There are already thousands of patients who have achieved complete recovery through clinical trials both domestically and internationally.
This diabetic foot regeneration treatment can be extended to all skin regeneration conditions, including bedsores, burns, wounds, plastic surgery, and skin cancer.
Clinical trials for skin cancer were also conducted with plastic surgeons in Korea and Japan to prove its effectiveness.

--- p.27~28

The most common cause of reduced healthy life expectancy is complex chronic diseases.
It refers to the simultaneous progression of two or more chronic diseases, such as hypertension, arthritis, diabetes, hyperlipidemia, and renal failure.
In Korea, 40% of adults aged 20 or older suffer from at least one chronic disease, and 20% of them suffer from two or more complex chronic diseases.
The prevalence rate increases sharply from age 40 to 70, reaching 35.6% in those aged 45 to 64, 74.2% in those aged 65 and older, and 89.2% in those aged 75 and older.

The problem of chronic illness does not end with mere physical pain.
The economic burden mentioned earlier is another disaster.
The average household medical expenses were 1,326,000 won in 2018, but for households with chronic diseases, the average medical expenses increased to 2,329,000 won.
56% higher.
The social burden of medical expenses for chronic diseases is also significant.
Of the approximately 86.7 trillion won in benefits paid by the National Health Insurance Service in 2020, approximately 36.23 trillion won was spent on 12 chronic diseases alone.
Of the National Health Insurance Corporation's total expenditures, 42% was spent on treating chronic diseases.
This is not just a problem in our country.
In the United States, the proportion of patients with multiple chronic diseases is as high as 30%, and treatment costs account for 85% of total health care spending.
--- p.33

“Most treatments today are designed for the average patient.
However, successful treatment for some patients does not translate equally to others.
Precision medicine will provide personalized treatment options for each individual.”

On January 30, 2015, US President Barack Obama announced the launch of the Hyper-Personalized Precision Medicine Initiative in his State of the Union address at the White House.
The total budget allocated for this project amounted to 215 million dollars (approximately 256 billion won).
On that day, White House Press Secretary Lindsay Holst pointed out the "limits of average treatment" and declared that future medical care must evolve toward precision medicine.

--- p.37

The dictionary definition of 'treatment', which we commonly use, is 'to treat and cure an illness or wound.'
But if you add the word 'law' to this, the content becomes truly vast.
Representative treatments include internal medicine and surgical treatments.
There are also physical therapies that utilize physical methods, such as phototherapy and ultrasound therapy.
However, the ultimate goal of various treatments is generally the same.
It is to restore its form and function.


With the advent of the 4P medical era, the topics being discussed in the medical field are diverse.
The Fourth Industrial Revolution's diverse technologies, including precision medicine, companion diagnostics, targeted therapies, personalized treatments, minimally invasive procedures, and robotic surgery, are impacting the entire healthcare landscape.
Hyper-personalized regenerative medicine is also one of the most active research and clinical fields.
Hyper-personalized regenerative medicine is a cutting-edge medical field that regenerates various organs, tissues, and cells that make up the body, restoring or replacing their original form and function.
Restores tissues or organs that were previously unable to recover by activating the body's own healing mechanisms or replacing damaged tissue.

--- p.40

"Isn't there a law that makes life possible?" "If so, what is it?" After pondering these arrogant questions, I began my own study to find the law.
At the starting point was the hope that an answer could be found based on the principle of simplicity, Occam's Razor.
I expected and wanted to find a 'law of life' that was faithful to the principle of economy or the principle of frugality.
I hoped to discover a universally valid 'operating principle of life' that could be explained with a small amount of logic and without requiring many assumptions.

But the first thing I noticed was the solid wall of 'absence of macroscopic interpretation'.
Previous research into the principles of life has focused on the microscopic. Most studies, including DNA, have been based on reductionism.
There has not been much research or assumptions about the axioms that permeate the entire human body.
In particular, there was no explanation of the principles that make it possible for the human body to 'heal itself' from a systems engineering perspective.

--- p.47~48